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孙磊：博士、英国正版365首页官网研究员、博士生导师。研究方向免疫药理学，重点探索炎症性疾病中巨噬细胞功能可塑性的机制研究及鉴定新型药物作用靶标，特别是蛋白质翻译后修饰对炎症相关信号通路分子的调控机制。目前以通讯作者或第一作者发表SCI论文50余篇，其中包括Nature Microbiology，Nature Communications，Journal of Experimental Medicine，Acta Pharmaceutica Sinica B，Pharmacological Research，Cell Host & Microbe等高影响因子专业期刊。主持国家自然科学基金5项，上海市自然科学基金1项，教育部基金1项。论文他引次数达2900余次，H因子为30。担任中国药理学会呼吸药理专委会常务委员，中国药理学会抗炎免疫药理专委会青年委员，获“第十二届全国抗炎免疫药理学学术交流会”青年论文三等奖，上海交通大学“晨星青年学者”奖励计划，上海交通大学李兰馨青年教师奖励基金及上海交通大学第五届青教赛三等奖。

学术兼职情况：
1.中国药理学会呼吸药理专委会常务委员
2.中国药理学会抗炎免疫药理专委会青年委员会委员
3.中国免疫学会会员
4.上海药学会会员
5.上海免疫学会会员

教学情况：
1.研究生《免疫药理学》
2.本科生《微生物学与免疫学》

1. 固有免疫细胞应答机制与慢性炎症性疾病机制研究。
2. 炎症性疾病抗炎免疫药理。

1.Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun* and Feng Qian*. LMO7 Suppresses Tumor-Associated Macrophage Phagocytosis of Tumor Cells through Degradation of LRP1. Advanced Science 2025 doi:10.1002/advs.202511162.
2.Haibo Zhang, Keke Xue, Wen Li, Xinyi Yang, Yusen Gou, Xiao Su, Feng Qian*, Lei Sun*. Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity. Nature communications 2024 Jan 4;15(1):252. (IF: 16.6)
3.Shixin Duan, Xinyi Lou, Shiyi Chen, Hongchao Jiang, Dongxin Chen, Rui Yin, Mengkai Li, Yuseng Gou, Wenjuan Zhao, Lei Sun*, Feng Qian*. Macrophage LMO7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming. Acta Pharm Sin B. 2023 Dec;13(12):4785-4800. (IF: 14.5)
4.Lei Sun*, Haibo Zhang, Huihui Zhang, Xinyi Lou, Zhiming Wang, Yaxian Wu, Xinyi Yang, Daijie Chen, Beining Guo, Ao Zhang, Feng Qian*. Intracellular Staphylococcus aureus utilizes endoplasmic reticulum-resident E3 ubiquitin ligase AMFR to promote pneumonia via virulent -hemolysin B. Nature Microbiology. 2023, Jan 2; 8 (107–120). (IF: 30.964) (corresponding author)
5.Huihui Zhang, Ran Wei, Xinyi Yang, Lu Xu, Hongchao Jiang, Mengkai Li, Haixia Jiang, Haibo Zhang, Zhihong Chen, Feng Qian*, Lei Sun*. AMFR drives allergic asthma development by promoting alveolar macrophage-derived GM-CSF production. Journal of Experimental Medicine. 2022 May 2;219(5):e20211828. (IF: 17.579) (corresponding author)
6.Huihui Zhang, Feng Qian*, Lei Sun*. Autocrine motility factor receptor as a therapeutic target for asthma: comments on 'AMFR drives allergic asthma development by promoting alveolar macrophage-derived GM-CSF production'. J Mol Cell Biol. 2022 Aug 26;14(5). (IF: 8.185) (corresponding author)
7.Hongchao Jiang, Yaxue Zhao, Huirong Tang, Shixin Duan, Mengkai Li, Xinyi Yang, Jingting Liu, Xinyi Lou, Yuanyuan Cai, Wenjuan Zhao, Lei Sun*, Feng Qian *. Tetraethylthiuram disulphide alleviates pulmonary fibrosis through modulating transforming growth factor-β signalling. Pharmacol Res. 2021 Dec; 174: 105923. (IF: 10.334) (corresponding author)
8.Qing Liang, Wuyang Cai, Yaxue Zhao, Huanbai Xu, Huirong Tang, Daijie Chen, Feng Qian*, Lei Sun*. Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis. Pharmacol Res. 2020 Aug; 158: 104884. (IF: 10.334) (corresponding author)
9.Xinyi Yang, Runsheng Li, Lu Xu, Feng Qian*, Lei Sun*. Serum amyloid A3 is required for caerulein-induced acute pancreatitis through induction of RIP3-dependent necroptosis. Immunol Cell Biol. 2021 Jan;99(1):34-48. (corresponding author)
10.Lei Sun, Qiong Wu, Yunjuan Nie, Ni Cheng, Rui Wang, Gang Wang, Dan Zhang, Huiqiong He, Richard D. Ye and Feng Qian: A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver Ischemia/Reperfusion Injury. Front Immunol, 2018, 9, 2610. (IF: 8.786)
11.Rui Hao*, Yunduan Song*, Runsheng Li, Yaxian Wu, Xinyi Yang, Xiaozong Li, Feng Qian*, Richard D Ye*, Lei Sun*. MLN4924 protects against interleukin-17A-induced pulmonary inflammation by disrupting ACT1-mediated signaling. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1070-L1080. (corresponding author)
12.Yunjuan Nie#, Lei Sun#, Yaoyao Yang, Jun Wang, Huiqiong He, Yanhua Chang, Yaxian Wu, Qing Liang, Yudong Hu, Jianwei Zhu, Richard D. Ye, John W. Christman, Feng Qian*. AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation. Journal of Immunology. 2017 Jun 1;198(11):4470-4480.
13.Ziyan Zhu, Lili Wang, Rui Hao, Bo Zhao, Lei Sun*, Richard D. Ye*. A cullin-5-TRAF6 interaction promotes TRAF6 polyubiquitination and lipopolysaccharide signaling. Journal of Immunology. 2016 July 1;197 (1):21-26. (corresponding author)
14.Lei Sun#, Huibin Zhou#, Ziyan Zhu, Qian Yan, Lili Wang, Qing Liang, Richard D. Ye*. Ex vivo and in vitro effect of Serum Amyloid A in the induction of macrophage M2 markers and efferocytosis of apoptotic neutrophils. Journal of Immunology. 2015 May 15;194(10):4891-900.
15.Ling Kong#, Lei Sun#, Hong-Xin Zhang, Qin Liu, Ye Liu, Lin-Hua Qin, Guo-Jun Shi, Jun-Hao Hu, A-Jing Xu, Yue-Ping Sun, Dang-Sheng Li, YuFang Shi, Jing-Wu Zang, Jiang Zhu, Zhu Chen, Zhu-Gang Wang, Bao-Xue Ge*. An essential role for RIG-I in Toll-like receptor-stimulated phagocytosis. Cell Host &Microbe. 2009 Aug 20;6(2): 150-61. (IF: 31.316)

纵向基金资助情况：
1.自然科学基金面上项目，微黄奈瑟菌效应蛋白ThiF靶向降解EGR1诱导肺泡巨噬细胞衰老和中性粒细胞型哮喘的机制研究及药靶鉴定，2025／01-2028／12，主持，在研。
2.自然科学基金面上项目，82273934、Cullin-5通过脂滴包被蛋白Plin5诱导肺泡巨噬细胞致炎表型介导重症哮喘的机制研究及药靶鉴定、2023／01-2026／12、主持，在研。
3.自然科学基金面上项目，主持，2021年1月至2024年12月（82073858）：E3泛素连接酶LMO7促进巨噬细胞焦亡增强特发性肺纤维化的机制研究及药物靶标鉴定、主持，结题。
4.上海市自然科学基金项目，衰老相关代谢物甲基丙二酸通过E泛素连接酶AMFR诱导氧化应激异常促进特发性肺纤维化的机制研究及药物靶标鉴定，2021／07-2023／06，主持，结题。
5.自然科学基金应急管理项目，主持，2018年1月至2018年12月（31741038）：Cullin 5在SAA诱导的非感染性炎症中的作用及机制研究。
6.国家自然科学基金青年基金项目，主持，2013年1月至2015年12月（81202316）：2型甲酰肽受体调控M2 型巨噬细胞极化的分子机制以及其在炎症反应中的作用。
7.教育部博士点专项科研基金新教师基金，主持，2013年1月至2015年12月（20120073120092）：血清淀粉样蛋白A（SAA）抑制Th17细胞分化的机制研究及其在炎症性肠部中的作用。